Infectious Transmission of Human T-cell Lymphotropic Virus Type I1 in Rabbits
نویسندگان
چکیده
To determine the susceptibility of rabbits to experimental infection with human T-cell lymphotropic virus type4 (HTLV11). four separate groups of four weanling rabbits each were inoculated intravenously with lethally irradiated HTLV-IIinfected human cell lines Mo-T (HTLV-11,-infected T cells), WIL-NRA (an Epstein-Barr virus [EBVI-transformed B-lymphoblastoid cell line infected with HTLV-I,), 729pH6neo (an EBV-transformed lymphoblastoid cell line transfected with a molecular clone of HTLV-11,). or G12.1 (HTLV-ll-infected T cells from a Panamanian Guaymi Indian). Two additional groups of four rabbits each were similarly inoculated with control uninfected 729 or HUT 78 cells. Early and persistent seroconversion to HTLV-II core antigen p24, as determined by Western immunoblot, occurred in all HTLV-ll-inoculated rabbits and was most intense in rabbits inoculated with G12.1 cells; seroreqctivity to other HTLV-II gag or env antigens occurred later, with less intensity, or not in all
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